Humoral Factor(s) in Experimental Hypersplenism

Humoral factor (s) in experimental hypersplenism.

I HE SYNDROME of hypersplenism is characterized by splenomegaly, selective or total blood cytopenias, normal or hyperplastic bone marrow, and disappearance of the cytopenias after splenectomy. The mechanism of the various forms of hypersplenism ( splenic thrombocytopenia, spenic anemia, splenic neutropenia, splenic pancytopenia ) is still under discussion. Clinical and experimental evidence has...

Influence of spleen on thrombocytopenia induced by humoral factor(s) of experimental hypersplenism.

I N A PREVIOUS communication’ evidence was presented for the existence of a humoral factor or factors FHF( s )] in rats with experimental methylcellulose-hypersplenism. The HF( s ) was shown to be eliminated with the urine of hypersplenic rats since such urine caused slight anemia and thrombocytopenia as low as 65 per cent of normal values when given intragastrically to normal rats. Similar adm...

Humoral Factors Influencing Erythropoiesis

STRONG EVIDENCE has accumulated to indicate that erythropoiesis in mammals is under the control of a circulating principle, the erythropoiesisstimulating factor ( ESF ) or erythropoietin.1’2 A similar regulatory system may be operative in amphibians and birds.3’4 The ESF appears in large quantities in the plasma of animals subjected to bleeding or low oxygen pressures’ and its production is inh...

Experimental Sepsis Impairs Humoral Memory in Mice

Patients with sepsis are often immune suppressed, and experimental mouse models of sepsis also display this feature. However, acute sepsis in mice is also characterized by a generalized B cell activation and plasma cell differentiation, resulting in a marked increase in serum antibody concentration. Its effects on humoral memory are not clearly defined. We measured the effects of experimental s...

Hypersplenism in cirrhosis.